Animal-Free IL-31 Protein, Mouse (His)

IL-31 Protein activates STAT3, potentially STAT1 and STAT5, through the IL31 receptor. It enhances myeloid progenitor cell survival and induces RETNLA and serum amyloid A protein expression in macrophages. IL-31 Protein's diverse functions suggest its importance in biological processes and potential implications in immune regulation and cell survival. Animal-Free IL-31 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-31 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-31 Protein, Mouse (His) is 140 a.a., with molecular weight of ~16.56 kDa.

IL-31 Protein activates STAT3 and potentially STAT1 and STAT5 through the IL31 heterodimeric receptor, which consists of IL31RA and OSMR. It has been suggested to play a role in skin immunity and enhances the survival of myeloid progenitor cells in vitro. IL-31 Protein also induces the expression of RETNLA and serum amyloid A protein in macrophages. These diverse functions highlight the significance of IL-31 Protein in various biological processes and suggest its potential implications in immune regulation and cell survival.

Mouse

E. coli

C-His

Q6EAL8 (T24-C163)

76399  [NCBI]

MTCSLSFGAPISKEDLRTTIDLLKQESQDLYNNYSIKQASGMSADESIQLPCFSLDREALTNISVIIAHLEKVKVLSENTVDTSWVIRWLTNISCFNPLNLNISVPGNTDESYDCKVFVLTVLKQFSNCMAELQAKDNTTC

Approximately 16.56 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a solution containing 1X PBS, pH 7.4, trehalose.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.