Animal-Free Neurotrophin-3 Protein, Human

Animal-Free Neurotrophin-3 Protein, Human is a recombinant Neurotrophin-3 protein expressed in E. coli system. Neurotrophin-3 is widely expressed in the nervous system. Neurotrophin-3 reduces cellular damage, improves neuronal regeneration in different models of lesions^[1].

Neurotrophin-3 (NT-3), a trophic factor from the neurotrophin family, is widely expressed in the nervous system.
The physiological actions of NT-3 are mediated by the activation of two membrane receptors: the low-affinity receptor p75 and the high-affinity receptor Trk. NT-3 activates the TrkC receptor and binds with less affinity to TrkB and TrkA.
NT-3 reduces cellular damage, improves neuronal regeneration in different models of lesions or neurodegeneration, and participates in synaptic reorganization, synapse formation, and neuronal plasticity^[1].

Neurotrophin-3 (human; 2 ng/mL; 20 h), but not brain-derived neurotrophic factor, promotes neuronal differentiation of retinal progenitor E4 cells^[3].

Human

E. coli

Tag free

P20783-1 (Y139-T257)

4908

YAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT

Approximately 14.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.