APCDD1 Protein, Mouse (HEK293, His)

The APCDD1 protein acts as a negative regulator, cell-autonomously inhibiting the Wnt signaling pathway and upstream of β-catenin. Its proposed mode of action involves interactions with Wnt and LRP proteins, suggesting a role in regulating the Wnt signaling cascade. APCDD1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived APCDD1 protein, expressed by HEK293 , with C-His labeled tag. The total length of APCDD1 Protein, Mouse (HEK293, His) is 466 a.a., with molecular weight of 65-68 kDa.

APCDD1 protein serves as a negative regulator of the Wnt signaling pathway, exerting its inhibitory influence in a cell-autonomous manner and operating upstream of beta-catenin. Its mode of action is proposed to involve interactions with Wnt and LRP proteins, suggesting a role in modulating the intricate Wnt signaling cascade. Functioning as a homodimer, APCDD1 engages in molecular interactions with key components of the Wnt pathway, including LRP5 and WNT3A. These interactions contribute to the protein's regulatory role in suppressing Wnt signaling, highlighting its involvement in cellular processes crucial for proper development and homeostasis.

Mouse

HEK293

C-His

Q3U128 (L27-T492)

494504  [NCBI]

65-68 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.