ARMET/MANF Protein, Human (HEK293, Fc)

ARMET/MANF Protein is an evolutionary conserved endoplasmic reticulum stress- (ERS-) related protein. ARMET/MANF has a protective effect on central nervous system diseases and plays an important role in several metabolic diseases. It is mainly localized to the luminal endoplasmic reticulum (ER) as an ER chaperone protein, mainly interacting with BiP and Reticulon 1-C. Meanwhile, MANF can prevent ER stress-mediated cell death in neurons and other tissues. ARMET/MANF Protein, Human (HEK293, Fc) is the recombinant human-derived ARMET/MANF protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ARMET/MANF Protein, Human (HEK293, Fc) is 182 a.a., with molecular weight of ~44.9 KDa.

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an evolutionary conserved endoplasmic reticulum stress- (ERS-) related protein. MANF is widely expressed in the brain of invertebrates and vertebrates, as well as peripheral nonneuronal tissues. MANF has a protective effect on central nervous system diseases and plays an important role in several metabolic diseases. MANF is mainly localized to the luminal endoplasmic reticulum (ER) as an ER chaperone protein, mainly interacting with BiP and Reticulon 1-C. Further, following a range of ER stress, MANF expression significantly enhanced with increasing receptors activating transcription factor 6 (ATF6) and transcription factor X-box binding protein 1 (XBP1), both of which are ER stress markers. Meanwhile, MANF can prevent ER stress-mediated cell death in neurons and other tissues, such as the liver, heart, and kidney. It can be used in reaserch on Parkinson’s disease (PD), Alzheimer’s disease, stroke, and diabetes^[1].

Human

HEK293

C-hFc

A8K878 (M1-L182)

7873  [NCBI]

Approximately 44.9 kDa.

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.