2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Neurotrophic Factors
  5. CDNF/MANF family

CDNF/MANF family

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Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) form a new neurotrophic factors family (NTFs) of evolutionarily conserved and may not act as classical, target-derived neurotrophic factors (NTFs) that are solely secreted proteins. CDNF is a vertebrate specific paralogue of MANF. CDNF/MANF are mostly intracellular and localize to the endoplasmic reticulum (ER) under normal conditions and protect cells from ER stress, and regulate the unfolded protein response via interacting with chaperons, and CDNF dissolves intracellular α-synuclein aggregates. In animal models of Parkinson's disease (PD), CDNF protects and repairs dopamine (DA) neurons, regulates ER stress, and improves motor function more efficiently than other NTFs.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P71940A
    ARMET/MANF Protein, Human (His)

    Arginine rich mutated in early stage tumors; Arginine rich protein; Arginine-rich protein; ARMET; ARMET protein; ARP; Manf; MANF_HUMAN; Mesencephalic astrocyte derived neurotrophic factor; Mesencephalic astrocyte-derived neurotrophic factor; MGC142148; MGC142150; Protein ARMET

    		Human E. coli
    ARMET/MANF proteins critically support the survival of dopaminergic neurons in the ventral midbrain and contribute to neuronal homeostasis. It modulates GABAergic transmission and enhances inhibitory postsynaptic currents in substantia nigra dopaminergic neurons. ARMET/MANF Protein, Human (His) is the recombinant human-derived ARMET/MANF protein, expressed by E. coli , with N-6*His labeled tag. The total length of ARMET/MANF Protein, Human (His) is 158 a.a., with molecular weight of ~20 kDa.
  • HY-P70069
    CDNF Protein, Human (HEK293, His)

    rHuCerebral dopamine neurotrophic factor/CDNF, His ; Cerebral dopamine neurotrophic factor; ARMET-like protein 1; Conserved dopamine neurotrophic factor; ARMETL1

    		Human HEK293
    CDNF (cerebral dopamine neurotrophic factor) functions as an important trophic factor, providing unique support to dopamine neurons. Its protective effect has a clear role in preventing 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. CDNF Protein, Human (HEK293, His) is the recombinant human-derived CDNF protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P7605
    ARMET/MANF Protein, Human (HEK293, His)

    rHuARMET/MANF, His; Mesencephalic astrocyte-derived neurotrophic factor; ARMET

    		Human HEK293
    ARMET/MANF Protein, Human (HEK293, His) expresses in HEK293 cells with a His tag. Armet/MANF, localized in the ER and Golgi, is a secreted protein and acts as a gene up-regulated by various forms of ER stress.
  • HY-P700038AF
    Animal-Free CDNF Protein, Human (His)

    Cerebral dopamine neurotrophic factor; ARMET-like protein 1; Conserved dopamine neurotrophic factor; ARMETL1

    		Human E. coli
    CDNF (cerebral dopamine neurotrophic factor) functions as an important trophic factor, providing unique support to dopamine neurons. Its protective effect has a clear role in preventing 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. Animal-Free CDNF Protein, Human (His) is the recombinant human-derived animal-FreeCDNF protein, expressed by E. coli , with C-His labeled tag.
  • HY-P77296
    ARMET/MANF Protein, Mouse (HEK293, His)

    Mesencephalic astrocyte-derived neurotrophic factor; Arginine-rich protein; ARP

    		Mouse HEK293
    ARMET/MANF proteins regulate the survival of dopaminergic neurons in the ventral midbrain and modulate GABAergic transmission to dopaminergic neurons in the substantia nigra. It enhances GABA inhibitory currents and inhibits cell proliferation while preventing ER stress-induced cell death. ARMET/MANF Protein, Mouse (HEK293, His) is the recombinant mouse-derived ARMET/MANF protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P700166AF
    Animal-Free CDNF Protein, Mouse (His)

    Cerebral dopamine neurotrophic factor; CDNF; ARMETL1

    		Mouse E. coli
    CDNF (cerebral dopamine neurotrophic factor) emerges as a key trophic factor for dopamine neurons that counteracts 6-hydroxydopamine (6-OHDA)-induced degeneration. Notably, it can restore dopaminergic function and prevent nigral neuronal degeneration after 6-OHDA injury. Animal-Free CDNF Protein, Mouse (His) is the recombinant mouse-derived animal-FreeCDNF protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free CDNF Protein, Mouse (His) is 163 a.a., with molecular weight of ~19.47 kDa.
  • HY-P76248
    CDNF Protein, Human (HEK293, Fc)

    Cerebral dopamine neurotrophic factor; ARMET-like protein 1; ARMETL1

    		Human HEK293
    CDNF (cerebral dopamine neurotrophic factor) functions as an important trophic factor, providing unique support to dopamine neurons. Its protective effect has a clear role in preventing 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. CDNF Protein, Human (HEK293, Fc) is the recombinant human-derived CDNF protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P75670
    CDNF Protein, Mouse (HEK293, His)

    Cerebral dopamine neurotrophic factor; CDNF; ARMETL1

    		Mouse HEK293
    CDNF (cerebral dopamine neurotrophic factor) emerges as a key trophic factor for dopamine neurons that counteracts 6-hydroxydopamine (6-OHDA)-induced degeneration. Notably, it can restore dopaminergic function and prevent nigral neuronal degeneration after 6-OHDA injury. CDNF Protein, Mouse (HEK293, His) is the recombinant mouse-derived CDNF protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P76731
    ARMET/MANF Protein, Human (HEK293, Fc)

    Mesencephalic astrocyte-derived neurotrophic factor; Arginine-rich protein; ARP

    		Human HEK293
    ARMET/MANF Protein is an evolutionary conserved endoplasmic reticulum stress- (ERS-) related protein. ARMET/MANF has a protective effect on central nervous system diseases and plays an important role in several metabolic diseases. It is mainly localized to the luminal endoplasmic reticulum (ER) as an ER chaperone protein, mainly interacting with BiP and Reticulon 1-C. Meanwhile, MANF can prevent ER stress-mediated cell death in neurons and other tissues. ARMET/MANF Protein, Human (HEK293, Fc) is the recombinant human-derived ARMET/MANF protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ARMET/MANF Protein, Human (HEK293, Fc) is 182 a.a., with molecular weight of ~44.9 KDa.
Cat. No. Product Name Effect Purity