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  3. Transferases (EC 2)
  4. AURC Protein, Human (Sf9, GST)

AURC Protein, Human (Sf9, GST)

Cat. No.: HY-P701710
Handling Instructions

AURC is a key serine/threonine protein kinase that plays a critical regulatory role in mitosis as part of the chromosomal passenger complex (CPC), ensuring accurate chromosome alignment and segregation. It contributes to chromatin-induced microtubule stabilization and spindle assembly. AURC Protein, Human (Sf9, GST) is the recombinant human-derived AURC protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of AURC Protein, Human (Sf9, GST) is 308 a.a., .

For research use only. We do not sell to patients.

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Description

AURC is a key serine/threonine protein kinase that plays a critical regulatory role in mitosis as part of the chromosomal passenger complex (CPC), ensuring accurate chromosome alignment and segregation. It contributes to chromatin-induced microtubule stabilization and spindle assembly. AURC Protein, Human (Sf9, GST) is the recombinant human-derived AURC protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of AURC Protein, Human (Sf9, GST) is 308 a.a., .

Background

AURC, a serine/threonine-protein kinase, functions as a pivotal component of the chromosomal passenger complex (CPC), a critical regulator of mitosis. The CPC complex is indispensable at the centromere for ensuring accurate chromosome alignment and segregation, crucial for chromatin-induced microtubule stabilization and spindle assembly. In addition to its role in mitosis, AURC plays a role in meiosis, particularly in spermatogenesis. It shares redundant cellular functions with AURKB and can rescue an AURKB knockdown. Similar to AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC also phosphorylates CPC complex subunits BIRC5/survivin and INCENP, enhancing AURKC activity. Furthermore, AURC targets TACC1, a protein involved in cell division, by phosphorylating it at 'Ser-228'.

Species

Human

Source

Sf9 insect cells

Tag

N-GST

Accession

Q9UQB9 (S2-S309)

Gene ID

6795

Molecular Construction
N-term
GST
AURC (S2-S309)
Accession # Q9UQB9
C-term
Synonyms
AURKC; Aurora kinase C; Aurora 3; Aurora/IPL1-related kinase 3; ARK-3; Aurora-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C
Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

AURC Protein, Human (Sf9, GST) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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AURC Protein, Human (Sf9, GST)
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HY-P701710
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