B4GALT3 Protein, Human (HEK293, His)

B4GALT3 Protein, Human (HEK293, His) promotes cell proliferation and invasion in glioblastoma. B4GALT3 plays an important role in development tumourigenesis^[1].

B4GALT3 is upregulated in glioblastoma and predicts poor prognosis. Upregulation of B4GALT3 promotes GBM cell proliferation and invasion while the downregulation of B4GALT3 reduces GBM cell proliferation and invasion. B4GALT3 regulates cell proliferation and invasion via β-catenin and vimentin. B^[1]. B4GALT3 is an enzyme responsible for the generation of poly-N-acetyllactosamine and is involved in tumorigenesis^[2].

Human

HEK293

C-6*His

O60512 (R32-S392)

8703  [NCBI]

RSLSALFGRDQGPTFDYSHPRDVYSNLSHLPGAPGGPPAPQGLPYCPERSPLLVGPVSVSFSPVPSLAEIVERNPRVEPGGRYRPAGCEPRSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLPENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEENPHRFDLLVRTQNSWTQDGMNSLTYQLLARELGPLYTNITADIGTDPRGPRAPSGPRYPPGSSQAFRQEMLQRRPPARPGPLSTANHTALRGSHHHHHHH

Approximately 50.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Tao Wu, et al. B4GALT3 promotes cell proliferation and invasion in glioblastoma. Neurol Res. 2020 Jun;42(6):463-470.  [Content Brief]

  [2]. Yanrui Sun, et al. B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells. Cancer Lett. 2016 Jun 1;375(2):284-292.  [Content Brief]