BACH2 Protein, Human (Sf9)

BACH2 is a multifunctional transcriptional regulator that acts as both a repressor and an activator and recognizes Maf recognition elements (MAREs) to coordinate the transcriptional regulation of MAFKs. During oxidative stress, BACH2 induces apoptosis by inhibiting HMOX1. BACH2 Protein, Human (Sf9) is the recombinant human-derived BACH2 protein, expressed by Sf9 insect cells , with tag free. The total length of BACH2 Protein, Human (Sf9) is 840 a.a., .

BACH2, a versatile transcriptional regulator, exhibits dual roles as a repressor and activator. Recognizing Maf recognition elements (MARE), it coordinates transcriptional activation and repression in conjunction with MAFK. In response to oxidative stress, BACH2 induces apoptosis by repressing the antiapoptotic factor HMOX1. Moreover, it plays a pivotal role in adaptive immunity, critically contributing to the maintenance of regulatory T-cell function and B-cell maturation. BACH2 forms homodimers, disulfide-linked, and heterodimers with Maf-related transcription factors, emphasizing its involvement in complex regulatory networks. Additionally, BACH2 serves as a positive regulator of the nuclear import of actin, underscoring its diverse functions in cellular processes.

Human

Sf9 insect cells

Tag Free

Q9BYV9 (S2-T841)

60468

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.