2. Recombinant Proteins
  3. Cytokines and Growth Factors CAR-T Related Proteins CD Antigens Biotinylated Proteins Fluorescent-labeled Recombinant Proteins
  4. TNF Superfamily B Cell CD Proteins
  5. TNF Receptor Superfamily BCMA/CD269
  6. B Cell Maturation Antigen (BCMA)
  7. BCMA/TNFRSF17 Protein, Human (FITC, HEK293, His-Avi)

BCMA/TNFRSF17 Protein, Human (FITC, HEK293, His-Avi)

Cat. No.: HY-P700663
Handling Instructions

BCMA/TNFRSF17 Protein, a receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL, crucially promotes B-cell survival and regulates humoral immunity. Activating NF-kappa-B and JNK, BCMA/TNFRSF17 plays a pivotal role in immune response signaling pathways. It associates with TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6, indicating involvement in various cellular processes mediated by these adaptor proteins. BCMA/TNFRSF17 Protein, Human (FITC, HEK293, His-Avi) is the recombinant human-derived BCMA/TNFRSF17 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of BCMA/TNFRSF17 Protein, Human (FITC, HEK293, His-Avi) is 54 a.a., with molecular weight of 12 kDa & 15-17 kDa, respectively.

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Description

BCMA/TNFRSF17 Protein, a receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL, crucially promotes B-cell survival and regulates humoral immunity. Activating NF-kappa-B and JNK, BCMA/TNFRSF17 plays a pivotal role in immune response signaling pathways. It associates with TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6, indicating involvement in various cellular processes mediated by these adaptor proteins. BCMA/TNFRSF17 Protein, Human (FITC, HEK293, His-Avi) is the recombinant human-derived BCMA/TNFRSF17 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of BCMA/TNFRSF17 Protein, Human (FITC, HEK293, His-Avi) is 54 a.a., with molecular weight of 12 kDa & 15-17 kDa, respectively.
Background

The BCMA/TNFRSF17 protein serves as a receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL, exerting essential functions in promoting B-cell survival and contributing to the regulation of humoral immunity. Through its activation of NF-kappa-B and JNK, BCMA/TNFRSF17 plays a pivotal role in signaling pathways associated with immune responses. Additionally, it forms associations with TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6, suggesting its involvement in various cellular processes mediated by these adaptor proteins.
Species

Human
Source

HEK293
Tag

C-Avi;C-His
Accession

Q02223 (M1-A54)
Gene ID

608  [NCBI]
Molecular Construction
N-term
BCMA (M1-A54)
Accession # Q02223
His-Avi
C-term
Synonyms
CD269; TNFRSF17; BCMA; BCM; TNFRSF13A
Molecular Weight

12 kDa & 15-17 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

BCMA/TNFRSF17 Protein, Human (FITC, HEK293, His-Avi) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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