C2/Complement C2 Protein, Human (HEK293, Fc)

C2/Complement C2 protein is essential in the classical pathway of the complement system. Activated by factor C1, C2 is cleaved into C2b and C2a. As a serine protease, C2a interacts with C4b, generating the C3 or C5 convertase. This crucial process activates and amplifies the complement cascade. C2/Complement C2 Protein, Human (HEK293, Fc) is the recombinant human-derived C2/Complement C2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of C2/Complement C2 Protein, Human (HEK293, Fc) is 732 a.a., with molecular weight of 110-130 kDa.

C2/Complement C2 protein plays a crucial role in the classical pathway of the complement system. When activated by factor C1, C2 undergoes cleavage, resulting in the formation of two fragments: C2b and C2a. C2a, functioning as a serine protease, subsequently interacts with complement factor C4b, leading to the generation of the C3 or C5 convertase. This process is essential for the activation and amplification of the complement cascade.

Human

HEK293

C-hFc

P06681 (A21-L752)

717  [NCBI]

110-130 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.