C7/Complement component C7 Protein, Human (HEK293, Fc)

C7, also known as complement component C7 protein, is a key component of the membrane attack complex (MAC) and plays a key role in innate and adaptive immune responses. As a component of MAC, C7 actively participates in the formation of target cell plasma membrane pores. C7/Complement component C7 Protein, Human (HEK293, Fc) is the recombinant human-derived C7/Complement component C7 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of C7/Complement component C7 Protein, Human (HEK293, Fc) is 843 a.a., with molecular weight of ~118 kDa.

Complement component C7 is an integral part of the membrane attack complex (MAC), a crucial effector in the innate and adaptive immune responses. The MAC plays a pivotal role by forming pores in the plasma membrane of target cells, leading to cell lysis and destruction. C7 functions as a membrane anchor in this process, and it can exist as a monomer or dimer, with the potential to form multimeric rosettes when part of the C5b-7 complex. MAC assembly begins with the proteolytic cleavage of C5 into C5a and C5b, and subsequently, C5b binds sequentially to C6, C7, C8, and multiple copies of the pore-forming subunit C9. This orchestrated sequence highlights the essential role of C7 in the assembly of MAC, contributing to the immune system's ability to eliminate target cells.

Human

HEK293

C-hFc

P10643 (M1-Q843)

730  [NCBI]

Approximately 118 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of PBS, 5 % Trehalose, 8% Glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.