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  4. CaMKII beta/CAMK2B Protein, Human (Q13554-1, sf9, GST)

CaMKII beta/CAMK2B Protein, Human (Q13554-1, sf9, GST)

Cat. No.: HY-P702655
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CaMKII beta/CAMK2B is a calcium/calmodulin-dependent protein kinase that functions autonomously upon Ca(2+)/calmodulin binding and autophosphorylation. It plays an important role in dendritic spine and synapse formation, neuronal plasticity, and the regulation of skeletal muscle sarcoplasmic reticulum Ca(2+) transport. CaMKII beta/CAMK2B Protein, Human (Q13554-1, sf9, GST) is the recombinant human-derived CaMKII beta/CAMK2B, expressed by Sf9 insect cells , with GST labeled tag. The total length of CaMKII beta/CAMK2B Protein, Human (Q13554-1, sf9, GST) is 665 a.a.,

For research use only. We do not sell to patients.

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Description

CaMKII beta/CAMK2B is a calcium/calmodulin-dependent protein kinase that functions autonomously upon Ca(2+)/calmodulin binding and autophosphorylation. It plays an important role in dendritic spine and synapse formation, neuronal plasticity, and the regulation of skeletal muscle sarcoplasmic reticulum Ca(2+) transport. CaMKII beta/CAMK2B Protein, Human (Q13554-1, sf9, GST) is the recombinant human-derived CaMKII beta/CAMK2B, expressed by Sf9 insect cells , with GST labeled tag. The total length of CaMKII beta/CAMK2B Protein, Human (Q13554-1, sf9, GST) is 665 a.a.,

Background

CaMKII beta/CAMK2B, a calcium/calmodulin-dependent protein kinase, functions autonomously upon Ca(2+)/calmodulin-binding and autophosphorylation, playing pivotal roles in dendritic spine and synapse formation, neuronal plasticity, and the regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, this kinase exhibits an essential structural function, orchestrating the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural role is critical for the precise targeting of CaMK2A, a downstream effector of NMDAR, facilitating dendritic spine and synapse formation and sustaining synaptic plasticity for long-term potentiation (LTP) and hippocampus-dependent learning. Furthermore, in developing hippocampal neurons, CaMKII beta promotes dendritic tree arborization, and in mature neurons, it contributes to dendritic remodeling. Additionally, it plays a role in the modulation of skeletal muscle function in response to exercise, impacting sarcoplasmic reticulum (SR) Ca(2+) transport regulation. In slow-twitch muscles, it is involved in regulating SR Ca(2+) transport, while in fast-twitch muscles, it controls Ca(2+) release from the SR through phosphorylation of triadin and phospholamban. Responding to interferon-gamma (IFN-gamma) stimulation, CaMKII beta catalyzes the phosphorylation of STAT1, thereby stimulating the JAK-STAT signaling pathway. Moreover, under endoplasmic reticulum stress conditions, it phosphorylates the reticulophagy regulator RETREG1 at 'Ser-151', enhancing RETREG1 oligomerization and its membrane scission and reticulophagy activity.

Species

Human

Source

Sf9 insect cells

Tag

GST

Accession

Q13554-1 (A2-Q666)

Gene ID

816

Synonyms
Calcium/calmodulin-dependent protein kinase type II subunit beta; CAM2; CAMK2; CAMKB
Purity

Greater than 80 % as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

CaMKII beta/CAMK2B Protein, Human (Q13554-1, sf9, GST) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
CaMKII beta/CAMK2B Protein, Human (Q13554-1, sf9, GST)
Cat. No.:
HY-P702655
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