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  3. Transferases (EC 2)
  4. CAMKK1 Protein, Human (Sf9)

CAMKK1 Protein, Human (Sf9)

Cat. No.: HY-P701722
Handling Instructions

The CAMKK1 protein is a calcium/calmodulin-dependent kinase and a key player in calcium-triggered signaling cascades involved in various cellular processes. It phosphorylates multiple members of the CAMK1 family, including CAMK1, CAMK1D, CAMK1G, and CAMK4. CAMKK1 Protein, Human (Sf9) is the recombinant human-derived CAMKK1 protein, expressed by Sf9 insect cells , with tag free. The total length of CAMKK1 Protein, Human (Sf9) is 505 a.a., .

For research use only. We do not sell to patients.

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Description

The CAMKK1 protein is a calcium/calmodulin-dependent kinase and a key player in calcium-triggered signaling cascades involved in various cellular processes. It phosphorylates multiple members of the CAMK1 family, including CAMK1, CAMK1D, CAMK1G, and CAMK4. CAMKK1 Protein, Human (Sf9) is the recombinant human-derived CAMKK1 protein, expressed by Sf9 insect cells , with tag free. The total length of CAMKK1 Protein, Human (Sf9) is 505 a.a., .

Background

CAMKK1, a calcium/calmodulin-dependent protein kinase, plays a pivotal role in a proposed calcium-triggered signaling cascade that impacts various cellular processes. This kinase exhibits the ability to phosphorylate CAMK1, CAMK1D, CAMK1G, and CAMK4, suggesting its involvement in regulating multiple downstream effectors. CAMKK1 is particularly implicated in the modulation of cell apoptosis, where it promotes cell survival by phosphorylating AKT1/PKB. This phosphorylation event, in turn, inhibits the pro-apoptotic protein BAD (Bcl2-antagonist of cell death), highlighting the intricate regulatory role of CAMKK1 in cellular survival pathways. It has to underscore CAMKK1's significance in orchestrating calcium-dependent signaling cascades and its impact on the delicate balance between cell survival and apoptosis.

Species

Human

Source

Sf9 insect cells

Tag

Tag Free

Accession

Q8N5S9 (M1-S505)

Gene ID

84254

Molecular Construction
N-term
CAMKK1 (M1-S505)
Accession # Q8N5S9
C-term
Synonyms
CAMKK1; Calcium/calmodulin-dependent protein kinase kinase 1; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1; CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha
Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

CAMKK1 Protein, Human (Sf9) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CAMKK1 Protein, Human (Sf9)
Cat. No.:
HY-P701722
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