CASK Protein, Human (sf9)

CASK protein is a Mg(2+)-independent multidomain scaffold kinase that catalyzes phosphate transfer to proteins, including NRXN1, thereby contributing to synaptic transmembrane protein anchoring and ion channel trafficking. It plays a critical role in neural development, regulation of gene expression through TBR1 interactions, and mediates connections between the extracellular matrix, multiligands, and the actin cytoskeleton. CASK Protein, Human (sf9) is the recombinant human-derived CASK protein, expressed by Sf9 insect cells , with tag free. The total length of CASK Protein, Human (sf9) is 897 a.a., with molecular weight of ~102 kDa.

The CASK Protein is a multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes phosphotransfer from ATP to various proteins, including NRXN1. It plays a pivotal role in synaptic transmembrane protein anchoring and ion channel trafficking, contributing to neural development and the regulation of gene expression through interaction with the transcription factor TBR1. CASK binds to cell-surface proteins like amyloid precursor protein, neurexins, and syndecans, suggesting its involvement in mediating connections between the extracellular matrix and the actin cytoskeleton, potentially through interactions with syndecan and the actin/spectrin-binding protein 4.1. Additionally, CASK is a component of the LIN-10-LIN-2-LIN-7 complex, which collaborates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules, highlighting its intricate role in cellular processes and neuronal function.

Human

Sf9 insect cells

Tag Free

O14936-4 (A2-Y898)

8573  [NCBI]

Approximately 102 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.