2. Recombinant Proteins
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  4. TNF Superfamily Stimulatory Immune Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Dendritic Cell CD Proteins
  5. TNF Receptor Superfamily 4-1BB
  6. 4-1BB
  7. CD137/4-1BB Protein, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His)

CD137/4-1BB Protein, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His)

Cat. No.: HY-P76200
Handling Instructions

CD137, also known as 4-1BB, is a protein that exhibits defects in conserved residues required for feature annotation propagation. Specific residues missing in CD137 prevent the propagation of certain functional features associated with this protein. CD137/4-1BB Protein, Rhesus Macaque (Biotinylated, HEK293, His) is the recombinant Rhesus Macaque-derived CD137/4-1BB protein, expressed by HEK293 , with C-His labeled tag.

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Description

CD137, also known as 4-1BB, is a protein that exhibits defects in conserved residues required for feature annotation propagation. Specific residues missing in CD137 prevent the propagation of certain functional features associated with this protein. CD137/4-1BB Protein, Rhesus Macaque (Biotinylated, HEK293, His) is the recombinant Rhesus Macaque-derived CD137/4-1BB protein, expressed by HEK293 , with C-His labeled tag.
Background

CD137, also known as 4-1BB, is a protein that exhibits a deficiency in conserved residue(s) required for the propagation of feature annotation. The specific residue(s) that are missing in CD137 hinder the propagation of certain functional characteristics associated with this protein. CD137 is a member of the tumor necrosis factor receptor (TNFR) superfamily and plays a significant role in immune regulation and activation of immune cells.
In Vitro

4-1BB (Cynomolgus monkey) binds to STA551, and Uto-hIgG2 with Kd value of 25.1 nM and 13 nM, respectively[4].
Species

Rhesus Macaque; Cynomolgus
Source

HEK293
Tag

C-His
Accession

A9YYE7/F6W5G6 (L24-Q186)
Gene ID

102127961/708281  [NCBI]
Molecular Construction
N-term
4-1BB (L24-Q186)
Accession # A9YYE7/F6W5G6
His
C-term
Synonyms
CD137; ILA; TNFRSF9; 4-1BB ligand receptor; CDw137
Molecular Weight

Approximately 18.7 kDa.
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CD137/4-1BB Protein, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CD137/4-1BB Protein, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His)
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