CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His)

CD1C belongs to Group 1 of the transmembrane glycoprotein CD1 family. CD1C protein, as a key antigen-presenting molecule, has shown the ability to bind both self and non-self lipid and glycolipid antigens, mediating host defense against tuberculosis. CD1C is associated with breast cancer prognosis and immune invasion. CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) is a recombinant protein dimer complex containing Rhesus Macaque-derived CD1C-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His), has molecular weight of ~44.7 (33.1+ 11.6) KDa.

CD1C belongs to Group 1 of the transmembrane glycoprotein CD1 family. The CD1 molecule is expressed on the surface of many different human antigen-presenting cells (DC, monocytes, and some thymus cells). The CD1C protein, as a key antigen-presenting molecule, has shown the ability to bind both self and non-self lipid and glycolipid antigens, thereby facilitating their presentation to T cell receptors on natural killer T cells. Human group 1 CD1 molecules (CD1a, CD1b, and CD1c) bind to pools of lipid antigens expressed by mycobacteria and present them to specific T cells, thereby mediating an effective pathway for host defense against tuberculosis. CD1C is associated with breast cancer prognosis and immune invasion^[1][2][3].

Measured by its binding ability in a functional ELISA. Immobilized Rhesus Macaque CD1C-B2M Heterodimer, at 2μg/mL (100μL/well) can bind Anti-CD1C antibody. The ED₅₀ for this effect is 0.1125 μg/mL.

Rhesus Macaque

HEK293

C-6*His

NP_001139005 (Q21-F298)&NP_001040602 (I21-M119)

717148  [NCBI]&712428  [NCBI]

Approximately 38 & 12 kDa.

• 
  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.