Langerin/CD207 Protein, Mouse (His)

Langerin, also known as CD207, is a calcium-dependent lectin with mannose-binding specificity. Notably, it induces the formation of Birbeck granules (BG) and acts as an effective regulator of membrane stacking and zipping. Langerin/CD207 Protein, Mouse (His) is the recombinant mouse-derived Langerin/CD207 protein, expressed by E. coli , with N-His labeled tag.

Langerin, also known as CD207, is a calcium-dependent lectin with a specific affinity for mannose. This protein plays a crucial role in antigen uptake and processing. Langerin induces the formation of Birbeck granules (BGs) and acts as a potent regulator of membrane superimposition and zippering. It demonstrates binding capabilities not only to mannosylated glycans but also to sulfated glycans such as keratan sulfate (KS) and beta-glucans. As a homotrimer, Langerin facilitates the uptake of antigens and is involved in the routing and processing of antigens for presentation to T cells. The multifaceted functions of Langerin highlight its significance in immune response modulation and antigen presentation pathways.

Mouse

E. coli

N-His

Q8VBX4 (Q63-E331)

246278  [NCBI]

QAVFYPRLMGKILDVKSDAQMLKGRVDNISTLGSDLKTERGRVDDAEVQMQIVNTTLKRVRSQILSLETSMKIANDQLQILTMSWGEVDSLSAKIPELKRDLDKASALNTKVQGLQNSLENVNKLLKQQSDILEMVARGWKYFSGNFYYFSRTPKTWYSAEQFCISRKAHLTSVSSESEQKFLYKAADGIPHWIGLTKAGSEGDWYWVDQTSFNKEQSRRFWIPGEPNNAGNNEHCANIRVSALKCWNDGPCDNTFLFICKRPYVQTTE

Approximately 34 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.