CD316/IGSF8 Protein, Mouse (HEK293, Fc)

The CD316/IGSF8 protein plays a key role in functions related to CD81 and CD9, affecting oocyte fertilization and may affect HCV function. It regulates keratinocyte proliferation, acts as a negative regulator of cell motility, and binds to CD82 to inhibit prostate cancer cell migration. CD316/IGSF8 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD316/IGSF8 protein, expressed by HEK293 , with C-hFc labeled tag.

The CD316/IGSF8 protein appears to play a pivotal role in a variety of functions attributed to CD81 and CD9, such as oocyte fertilization and potential involvement in hepatitis C virus function. Additionally, it is implicated in regulating the proliferation and differentiation of keratinocytes and may act as a negative regulator of cell motility, suppressing T-cell mobility in coordination with CD81, associating with CD82 to suppress prostate cancer cell migration, and regulating epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as crucial linkers. CD316/IGSF8 might also contribute to integrin-dependent morphology and motility functions, participating in the regulation of neurite outgrowth and the maintenance of the neural network in the adult brain. Interactions with CD82, CD9/tetraspanin-29, integrin alpha-3/beta-1, and integrin alpha-4/beta-1 are suggested, with additional participation in a complex composed of CD9, PTGFRN, and CD81. Furthermore, direct interaction with CD81/tetraspanin-28 is noted, emphasizing the intricate network of associations that define the diverse roles of CD316/IGSF8 in cellular processes.

Mouse

HEK293

C-hFc

Q8R366 (R26-T577)

140559  [NCBI]

Approximately 80 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.