CD38 Protein, Human (HEK293, His, solution)

The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, His, solution) is the recombinant human-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag.

The CD38 Protein assumes a pivotal role in cellular signaling, being a proficient synthesizer of cyclic ADP-ribose (cADPR), a recognized second messenger crucial for glucose-induced insulin secretion. Moreover, it facilitates the synthesis of the calcium mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), derived from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. Operating at both pH 5.0 and pH 7.4, CD38 Protein exhibits a preference for transforming 2'-phospho-cADPR into NAADP(+) while selectively cleaving NADP(+) to cADPR and ADPRP rather than generating NADDP(+). Notably, it also showcases cADPR hydrolase activity, highlighting its multifaceted role in the dynamic regulation of these crucial signaling molecules. The integration of these activities underscores the significance of CD38 Protein in modulating cellular responses, particularly in the context of insulin secretion and calcium mobilization.

Human

HEK293

C-6*His

P28907 (V43-I300)

952  [NCBI]

VPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI

38-50 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.