CD39 Protein, Human (sf9, His)

The CD39 protein is an important regulator in the nervous system, coordinating purinergic neurotransmission by hydrolyzing ATP and other nucleotides. Its enzymatic ability can hydrolyze platelet-activated ADP into AMP, thereby effectively preventing platelet aggregation. CD39 Protein, Human (sf9, His) is the recombinant human-derived CD39 protein, expressed by Sf9 insect cells , with C-His labeled tag.

In the nervous system, the CD39 protein serves as a key regulator of purinergic neurotransmission by hydrolyzing ATP and other nucleotides. Its enzymatic activity extends to the prevention of platelet aggregation, as it efficiently hydrolyzes platelet-activating ADP to AMP. Notably, CD39 exhibits equal proficiency in the hydrolysis of both ATP and ADP, emphasizing its versatile role in modulating purinergic signaling pathways and contributing to the intricate regulation of neurotransmission and platelet function.

Measured by its ability to hydrolyze the 5’-phosphate groups from the substrate adenosine-5’-triphosphate (ATP) and the specific activity is >5000 pmol/min/µg.

Human

Sf9 insect cells

C-His

P49961 (T38-V478)

953  [NCBI]

Approximately 56.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.1.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.