CD96 Protein, Human (C110S, HEK293, His)

CD96 facilitates adhesive interactions of activated T and NK cells in the late phase of the immune response. It promotes adhesion between NK cells and target cells by interacting with PVR on the target cells. This interaction occurs after T and NK cells have penetrated the endothelium using integrins and selectins, actively engaging diseased cells within areas of inflammation. CD96 forms homodimers linked by disulfide bonds and interacts with PVR. CD96 Protein, Human (C110S, HEK293, His) is the recombinant human-derived CD96 protein, expressed by HEK293 , with C-His labeled tag and C110S mutation. The total length of CD96 Protein, Human (C110S, HEK293, His) is 482 a.a., with molecular weight of 100-130 kDa.

CD96 protein appears to play a role in adhesive interactions during the late phase of the immune response, potentially involving activated T and NK cells. It facilitates NK cell-target adhesion by interacting with PVR present on target cells. CD96 may function in a phase after T and NK cells have penetrated the endothelium using integrins and selectins, actively engaging with diseased cells and navigating within areas of inflammation. Structurally, CD96 forms homodimers through disulfide linkages and interacts specifically with PVR, suggesting its involvement in cell-cell interactions crucial for immune responses during inflammation and infection.

Human

HEK293

C-His

P40200-2 (V22-M503, C110S)

10225  [NCBI]

100-130 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<0.1 EU/μg, determined by LAL method.