CDC37 Protein, Mouse (sf9)

The CDC37 protein is a co-chaperone that binds to kinases and promotes their interaction with Hsp90 complexes, thereby stabilizing and activating them. It inhibits the ATPase activity of HSP90AA1. CDC37 Protein, Mouse (sf9) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes), , , , mutation. The total length of CDC37 Protein, Mouse (sf9) is 379 a.a., with molecular weight of ~46 kDa.

CDC37 protein is a co-chaperone that binds to various kinases and facilitates their interaction with the Hsp90 complex, leading to the stabilization and activation of these kinases. It inhibits the ATPase activity of HSP90AA1. It is likely to form a complex consisting of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1, and client protein TSC2. This complex may also include CDK4, AKT, RAF1, and NR3C1, but does not contain STIP1/HOP and PTGES3/p23. CDC37 forms a separate complex with Hsp90/HSP90AB1 and CDK6. It interacts with several proteins including HSP90AA1, AR, CDK4, CDK6, EIF2AK1, RB1, KSR1, FLCN, FNIP1, and FNIP2.

Mouse

Sf9 insect cells

Tag Free

Q61081 (N-G&P, M1-A379)

12539  [NCBI]

Approximately 46 kDa

Greater than 85% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.