2. Gene
  3. Cdc37 - cell division cycle 37 Gene

Cdc37 - cell division cycle 37 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p50; p50Cdc37

Gene ID: 12539 | Gene type: protein coding

About Cdc37

Summary

Enables HSP90 protein binding activity and kinase binding activity. Contributes to protein kinase regulator activity. Involved in positive regulation of Mitophagy in response to mitochondrial depolarization; posttranscriptional regulation of gene expression; and regulation of protein kinase activity. Located in cytosol. Part of HSP90-CDC37 chaperone complex. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human CDC37 (cell division cycle 37, HSP90 cochaperone). [provided by Alliance of Genome Resources, Apr 2022]

Cdc37 Products(2)

mRNA Protein Name
NM_001378796.1 NP_001365725.1 hsp90 co-chaperone Cdc37 isoform 1
NM_016742.5 NP_058022.1 hsp90 co-chaperone Cdc37 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
17189825 MGI
enables kinase binding IPI
IPI: Inferred from physical interaction
21855797 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23428871 MGI
contributes to protein kinase regulator activity IDA
IDA: Inferred from direct assay
21855797 MGI
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of type 2 mitophagy IDA
IDA: Inferred from direct assay
21855797 MGI
involved in post-transcriptional regulation of gene expression IDA
IDA: Inferred from direct assay
21855797 MGI
involved in regulation of protein kinase activity IDA
IDA: Inferred from direct assay
21855797 MGI
Cellular Component GO Annotation Evidence Reference Source
part of HSP90-CDC37 chaperone complex IDA
IDA: Inferred from direct assay
21855797 MGI
located in cytosol IDA
IDA: Inferred from direct assay
17189825 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hsp90 co-chaperone Cdc37

cell division cycle 37 homolog

hsp90 chaperone protein kinase-targeting subunit

Recombinant Cdc37 Proteins

Cat. No. Product Name Accession Purity
HY-P75362 CDC37 Protein, Mouse (sf9, His-GST) Q61081 (M1-A379) ≥95%
HY-P75363 CDC37 Protein, Mouse (sf9) Q61081 (N-G&P, M1-A379) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N1986 Cucurbitacin D Inhibitor 99.91% Unkown
HY-139301 DDO-5936 Inhibitor 99.20% Unkown
HY-144650 Hsp90-Cdc37-IN-3 98.09% Unkown
HY-N3417 Kongensin A ≥98.0% Unkown
HY-111414 Hsp90-Cdc37-IN-1 Inhibitor 99.66% Unkown
HY-119906 Conglobatin 95.48% Unkown
HY-130624 Hsp90-Cdc37-IN-2 / Unkown
HY-RS02297 CDC37 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02298 CDC37L1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdc37 NCBI NCBI:11140