2. Recombinant Proteins
  3. Enzymes & Regulators
  4. Transferases (EC 2) Serine/Threonine Kinase Proteins
  5. Cyclin-Dependent Kinases (CDKs)
  6. Cyclin-Dependent Kinase-like 2 (CDKL2)
  7. CDKL2 Protein, Human (sf9, His)

Cyclin-dependent kinase-like 2 (CDKL2), is a member of the CDC2-related serine/threonine protein kinase family. CDKL2 is tightly associated with tumor progression and is a regulator of epithelial-mesenchymal transition (EMT). CDKL2 also plays a role in cognitive functions, emotion, and neurological disorders. CDKL2 Protein, Human (sf9, His) is the recombinant human-derived CDKL2 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of CDKL2 Protein, Human (sf9, His) is 493 a.a., with molecular weight of ~63 KDa.

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Description

Cyclin-dependent kinase-like 2 (CDKL2), is a member of the CDC2-related serine/threonine protein kinase family. CDKL2 is tightly associated with tumor progression and is a regulator of epithelial-mesenchymal transition (EMT). CDKL2 also plays a role in cognitive functions, emotion, and neurological disorders[1][2]. CDKL2 Protein, Human (sf9, His) is the recombinant human-derived CDKL2 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of CDKL2 Protein, Human (sf9, His) is 493 a.a., with molecular weight of ~63 KDa.
Background

Cyclin-dependent kinase-like 2 (CDKL2), also known as P56 and KKIAMRE, is a member of the CDC2-related serine/threonine protein kinase family. CDKL2 is tightly associated with tumor progression, such as prostate cancer, breast cancer, hepatocellular carcinoma (HCC), glioma, and gastric cancer[1]. In addition, CDKL2 is a regulator of epithelial-mesenchymal transition (EMT) and can enhance mesenchymal traits and stem-cell like phenotypes of breast cancer cells[2]. CDKL2 also plays a role in cognitive functions, emotion, and neurological disorders[1].
Species

Human
Source

Sf9 insect cells
Tag

N-His
Accession

Q92772 (M1-H493)
Gene ID
Molecular Construction
N-term
His
CDKL2 (M1-H493)
Accession # Q92772
C-term
Synonyms
Cyclin-dependent kinase-like 2; Protein kinase p56 KKIAMRE; CDKL2
Molecular Weight

Approximately 63 kDa.
Purity

Greater than 80% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CDKL2 Protein, Human (sf9, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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