CEACAM1 Protein, Human (Biotinylated, HEK293, His-Avi)

CEACAM1 protein is involved in various biological processes. It is phosphorylated by the insulin receptor (INSR) in response to insulin stimulation, thereby promoting insulin clearance and regulating hepatic lipogenesis. CEACAM1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CEACAM1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

The SF3R gene is involved in various biological processes and functions. It regulates insulin action by promoting the clearance of insulin and regulating lipogenesis in the liver. Upon insulin stimulation, SF3R undergoes phosphorylation by the insulin receptor (INSR), leading to increased insulin endocytosis and degradation. This results in a reduction of fatty acid synthesis. SF3R also plays a role in down-regulating cell proliferation through its interaction with SHC1, which decreases the coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways.

Measured by its binding ability in a functional ELISA. Immobilized Biotinylated Human CEACAMI at 1 μg/mL on streptavidin coated plats can bind Anti-CEACAMI antibody. The EC ₅₀ is 0.3405-0.6093 ng/mL.

Human

HEK293

C-Avi;C-His

P13688-1 (Q35-G428)

634  [NCBI]

66-115 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized a 0.22 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.