CK1d Protein, Human (Sf9, GST)

The CK1d protein is an important serine/threonine protein kinase that complexly controls cellular processes such as Wnt signaling, DNA repair, and circadian rhythms. Its versatility is evident in phosphorylating a variety of proteins, including connexin-43/GJA1, MAP1A, p53/TP53, and YAP1. CK1d Protein, Human (Sf9, GST) is the recombinant human-derived CK1d protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of CK1d Protein, Human (Sf9, GST) is 414 a.a., .

CK1d Protein, an essential serine/threonine-protein kinase, intricately regulates cellular growth and survival processes encompassing Wnt signaling, DNA repair, and circadian rhythms. Demonstrating versatility, CK1d phosphorylates a diverse array of proteins, including connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1, and PER2. It plays a central role in the circadian clock, determining the period length through the regulation of PER1 and PER2 phosphorylation. Additionally, CK1d influences the WNT3A signaling pathway, neuronal outgrowth, ubiquitination of YAP1, DNA-binding activity of DNMT1, and numerous other cellular processes. This multifaceted kinase emerges as a key player in coordinating diverse cellular functions and signaling pathways.

Human

Sf9 insect cells

N-GST

P48730 (E2-R415)

1453

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.