CMG-2/ANTXR2 Protein, Human (HEK293, Fc)

CMG-2/ANTXR2 is essential for cellular interactions with laminin and the extracellular matrix. As a receptor for the protective antigen (PA) of B. anthracis, it undergoes heptamerization upon PA binding. The complex is internalized through a clathrin-dependent pathway, and in the endosomal membrane (pH < 7), it rearranges to form a pore, facilitating the entry of other components of anthrax toxin into the cytoplasm. CMG-2/ANTXR2 Protein, Human (HEK293, Fc) is the recombinant human-derived CMG-2/ANTXR2 protein, expressed by HEK293 , with C-hFc labeled tag.

CMG-2/ANTXR2 protein is essential for cellular interactions with laminin and the extracellular matrix. In the context of microbial infection, it serves as a receptor for the protective antigen (PA) of Bacillus anthracis. PA binding triggers the heptamerization of the receptor-PA complex, and this complex translocates to glycosphingolipid-rich lipid rafts, where it undergoes internalization through a clathrin-dependent pathway. Within the endosomal membrane and under acidic conditions (pH under 7), the complex undergoes rearrangement, forming a pore that facilitates the escape of other components of anthrax toxin into the cytoplasm. This process highlights the crucial role of CMG-2/ANTXR2 in the cellular response to B. anthracis infection and the subsequent internalization and translocation of anthrax toxin components.

Human

HEK293

C-hFc

P58335-4 (Q34-N317)

118429  [NCBI]

Approximately 57.4 kDa.

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.