2. Gene
  3. ANTXR2 - ANTXR cell adhesion molecule 2 Gene

ANTXR2 - ANTXR cell adhesion molecule 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HFS; ISH; JHF; CMG2; CMG-2

Gene ID: 118429 | Gene type: protein coding

About ANTXR2

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:79,901,146-80,073,472 (from NCBI)

This gene has 13 transcripts (splice variants), 268 orthologues, 2 paralogues and is associated with 4 phenotypes. Broad expression in prostate (RPKM 24.4), endometrium (RPKM 22.7) and 21 other tissues.

Summary

This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

ANTXR2 Products(4)

mRNA Protein Name
NM_001145794.2 NP_001139266.1 anthrax toxin receptor 2 isoform 2 precursor
NM_001286780.2 NP_001273709.1 anthrax toxin receptor 2 isoform 3
NM_001286781.2 NP_001273710.1 anthrax toxin receptor 2 isoform 3
NM_058172.6 NP_477520.2 anthrax toxin receptor 2 isoform 1 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15044490 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANTXR2 Protein Structure

VWA

VWA: von Willebrand factor type A domain (44 - 199)

Anth_Ig

Anth_Ig: Anthrax receptor extracellular domain (215 - 318)

Ant_C

Ant_C: Anthrax receptor C-terminus region (394 - 484)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 489 a.a.
Protein Preferred Names Protein Names

anthrax toxin receptor 2

capillary morphogenesis gene 2 protein

ANTXR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
ANTXR2 P58335 pagA Bacillus anthracis P13423
ITC
15044490
Cross
ANTXR2 P58335 pagA Bacillus anthracis P13423
FRET
15044490
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ANTXR2 Proteins

Cat. No. Product Name Accession Purity
HY-P76151 CMG-2/ANTXR2 Protein, Human (HEK293, Fc) P58335-4 (Q34-N317) ≥95%
HY-P700656 CMG-2/ANTXR2 Protein, Human (HEK293, His) P58335-4/NP_477520.2 (Q34-G318) ≥95%

Related Diseases

Diseases Alias
Hyaline Fibromatosis Syndrome

Juvenile Hyaline Fibromatosis

Inherited Systemic Hyalinosis

Puretic Syndrome

Infantile Systemic Hyalinosis

HFS

Hyalinosis, Systemic

Systemic Hyalinosis

Molluscum Fibrosum

Murray Syndrome

Murray-Puretic-Drescher Syndrome

Ish

Jhf

Fibromatosis, Juvenile Hyaline

Hyalinosis, Systemic Infantile

Fibromatosis, Hyaline Syndrome

Neurofibromatosis 1
Fibromatosis
Gingival Hypertrophy

Hypertrophy Of Gingivae
Anthrax Disease

Anthrax

Ragpicker'S Disease

Black Baine

Malignant Edema

Malignant Pustule

Siberian Plague

Wool Sorter'S Disease

Gas Gangrene

Cutaneous Anthrax

Anthrax Infection

Splenic Fever
Inhalation Anthrax

Pulmonary Anthrax

Respiratory Anthrax

Inhalational Anthrax

Wool-Sorters' Disease

Woolsorters' Disease

Inhalation Anthrax Disease

Respiratory Anthrax Disease
Cutaneous Anthrax

Anthrax, Skin Type

Skin Anthrax
Gastrointestinal Anthrax
Oropharyngeal Anthrax
Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin
Gapo Syndrome

GAPOS

Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy

Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome

Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy
Lipoid Proteinosis Of Urbach And Wiethe

Lipoid Proteinosis

Urbach-Wiethe Disease

Hyalinosis Cutis Et Mucosae

Lipid Proteinosis

Lipoproteinosis

Urbach Wiethe Disease

Lipoglycoproteinosis

Lipoidosis Cutis Et Mucosae

Lipoidproteinosis

Urbach-Wiethe Lipoid Proteinosis

Urbach-Wiethe Syndrome

LIP

Proteinosis Lipoid
Winchester Syndrome

WNCHRS

Winchester Disease

Winchester-Grossman Syndrome
Protein-Losing Enteropathy

Protein-Losing Enteropathies

Enteropathy, Exudative

Exudative Enteropathy

Ple - [Protein-Losing Enteropathy]
Gingival Disease

Gingival Diseases

Gum Disease

Gingival Disorder

Gingivitis And Periodontal Diseases
Stiff Skin Syndrome

SSKS

Stiff Skin
Oculoglandular Tularemia
Gingival Fibromatosis

Hereditary Gingival Fibromatosis

Hereditary Gingival Hyperplasia

Autosomal Dominant Gingival Fibromatosis

Autosomal Dominant Gingival Hyperplasia

Fibromatosis, Gingival, Hereditary

Fibromatosis, Gingival
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00756 ANTXR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ANTXR2 VGNC VGNC:25962
Rattus norvegicus ANTXR2 RGD RGD:1561294
Felis catus ANTXR2 VGNC VGNC:59838
Canis familiaris ANTXR2 VGNC VGNC:37936
Macaca mulatta ANTXR2 VGNC VGNC:69881
Mus musculus ANTXR2 MGD MGI:1919164
Others ANTXR2 NCBI