CNDP2 Protein, Mouse (HEK293, His)

CNDP2 Protein, an enzyme, plays a vital role in the metabolism of carnosine and homocarnosine. Dysregulation of CNDP2 Protein has been linked to diabetic nephropathy and neurodegenerative disorders. Targeting CNDP2 Protein may offer potential therapeutic strategies by regulating carnosine metabolism, improving renal function, and potentially treating these conditions. CNDP2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CNDP2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CNDP2 Protein, Mouse (HEK293, His) is 475 a.a., with molecular weight of 56-60 kDa.

The CNDP2 protein exhibits a unique function in catalyzing the hydrolysis of peptide bonds in dipeptides, particularly threonyl dipeptides. It plays a tissue-specific role in the catabolism of threonyl dipeptides. Additionally, CNDP2 protein displays significant dipeptidase activity towards cysteinylglycine, which is an intermediate metabolite in glutathione metabolism. It is also involved in the metabolism of N-lactoyl-amino acids, both by hydrolyzing them to form lactic acid and amino acids, as well as through reverse proteolysis to generate these compounds. Furthermore, CNDP2 protein contributes to the regulation of cell cycle arrest and apoptosis.

Mouse

HEK293

C-6*His

Q9D1A2 (M1-N475)

66054  [NCBI]

MSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMMEVAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEAYQKTGQEIPVNLRFCLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDNYWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLISLMGCLVDKKGKILIPGINDAVAPVTDEEHALYDHIDFDMEEFAKDVGAETLLHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPDMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHPHYQAGRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRLNYIEGTKMLAAYLYEVSQLKN

56-60 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.