1. Recombinant Proteins
  2. Cytokines and Growth Factors Receptor Proteins
  3. Neurotrophic Factors Cytokine Receptors
  4. Ciliary Neurotrophic Factor Receptor (CNTFR)
  5. CNTFR alpha Protein, Human (sf9, His)

CNTFR alpha Protein, Human (sf9, His)

Cat. No.: HY-P76275
Handling Instructions

CNTFR alpha protein is critical in protein folding, binding to cytosolic chaperone protein (c-CPN) and promoting the translocation of target proteins. It helps nascent polypeptide chains fold in different pathways. CNTFR alpha Protein, Human (sf9, His) is the recombinant human-derived CNTFR alpha protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of CNTFR alpha Protein, Human (sf9, His) is 324 a.a., with molecular weight of 45-48 KDa.

For research use only. We do not sell to patients.

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Description

CNTFR alpha protein is critical in protein folding, binding to cytosolic chaperone protein (c-CPN) and promoting the translocation of target proteins. It helps nascent polypeptide chains fold in different pathways. CNTFR alpha Protein, Human (sf9, His) is the recombinant human-derived CNTFR alpha protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of CNTFR alpha Protein, Human (sf9, His) is 324 a.a., with molecular weight of 45-48 KDa.

Background

The CNTFR alpha protein plays a crucial role in protein folding by specifically binding to cytosolic chaperonin (c-CPN) and facilitating the transfer of target proteins to it. It also binds to nascent polypeptide chains, aiding in their folding process within an environment where numerous alternative pathways for nonnative proteins exist. Structurally, the PFDN1 protein forms a heterohexamer consisting of two PFD-alpha type and four PFD-beta type subunits. Additionally, CNTFR alpha protein acts as a receptor for the heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. It also forms a complex with IL6ST/GP130 and IL27RA/WSX1 to interact with the neuroprotective peptide humanin. Furthermore, it forms a heterotrimer with LIFR and IL6ST and interacts with SORL1, potentially promoting internalization and lysosomal degradation.

Species

Human

Source

Sf9 insect cells

Tag

C-His

Accession

P26992 (Q23-P346)

Gene ID
Molecular Construction
N-term
CNTFR alpha (Q23-P346)
Accession # P26992
His
C-term
Synonyms
Ciliary neurotrophic factor receptor subunit alpha; CNTFR-alpha
Molecular Weight

45-48 kDa.

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CNTFR alpha Protein, Human (sf9, His)
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HY-P76275
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