CSNK1E Protein, Human (sf9, GST)

CSNK1E protein is a casein kinase that preferentially phosphorylates acidic proteins such as casein. CSNK1E Protein, Human (sf9, GST) is the recombinant human-derived CSNK1E, expressed by Sf9 insect cells , with GST labeled tag. The total length of CSNK1E Protein, Human (sf9, GST) is 415 a.a.,

CSNK1E, a member of the casein kinase family, is characterized by its preferential phosphorylation of acidic proteins, particularly caseins. The protein plays a pivotal role in Wnt signaling, as evidenced by its phosphorylation of DVL1 and DVL2, contributing to the intricate regulation of this pathway. Beyond its involvement in Wnt signaling, CSNK1E serves as a central component of the circadian clock, influencing the circadian period length by orchestrating the speed and rhythmicity of PER1 and PER2 phosphorylation. Acting in equilibrium with PP1, it governs the nuclear transport and degradation of PER1 and PER2, thereby intricately regulating the circadian rhythm. Additionally, CSNK1E demonstrates its regulatory influence by inhibiting cytokine-induced granulocytic differentiation, further emphasizing its multifaceted roles in cellular processes.

Human

Sf9 insect cells

GST

P49674 (E2-K416)

102800317

Greater than 80 % as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.