CSNK1G1 Protein, Human (sf9, His-GST)

The CSNK1G1 protein is a member of the casein kinase family that preferentially phosphorylates acidic proteins, including casein, exhibiting broad substrate specificity. Functionally, it actively participates in the Wnt signaling pathway and regulates cellular responses. CSNK1G1 Protein, Human (sf9, His-GST) is the recombinant human-derived CSNK1G1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

CSNK1G1, a serine/threonine-protein kinase belonging to the casein kinase family, is characterized by its operational definition involving the preferential phosphorylation of acidic proteins, including caseins. With a broad substrate specificity, it has the capability to phosphorylate a diverse array of proteins. Functionally, CSNK1G1 actively participates in the intricate Wnt signaling pathway, contributing to the modulation of cellular responses. Moreover, it plays a regulatory role in the rapid transmission of synaptic signals mediated by glutamate, demonstrating its involvement in synaptic processes and neurotransmitter signaling, as observed in other members of the casein kinase family. Notably, CSNK1G1 phosphorylates CLSPN, suggesting its role in influencing cellular processes associated with CLSPN-mediated functions.

Human

Sf9 insect cells

N-His;N-GST

Q9HCP0-1 (M1-K422)

53944  [NCBI]

Approximately 66 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.