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CSPG5 Protein, Human (HEK293, His)

Cat. No.: HY-P77833
Handling Instructions

The CSPG5 protein is a potential growth and differentiation factor that is actively involved in and critical for neural development. It may induce ERBB3 activation, a key pathway for cell growth and differentiation. CSPG5 Protein, Human (HEK293, His) is the recombinant human-derived CSPG5 protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.

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Description

The CSPG5 protein is a potential growth and differentiation factor that is actively involved in and critical for neural development. It may induce ERBB3 activation, a key pathway for cell growth and differentiation. CSPG5 Protein, Human (HEK293, His) is the recombinant human-derived CSPG5 protein, expressed by HEK293 , with C-His labeled tag.

Background

The CSPG5 protein emerges as a potential growth and differentiation factor, actively participating in neuritogenesis, a critical process in neural development. CSPG5 may exert its influence by inducing the activation of ERBB3, a key signaling pathway involved in cellular growth and differentiation. Additionally, CSPG5 exhibits binding affinity for TNR and likely TNC, suggesting potential interactions with extracellular matrix components. Furthermore, CSPG5 interacts with ERBB3 and GOPC, implicating its involvement in complex cellular signaling networks. Notably, the interaction with MDK, independent of chondroitin sulfate chains, promotes the elongation of oligodendroglial precursor-like cells, underscoring its role in supporting neural cell differentiation. These findings highlight the multifaceted nature of CSPG5 in orchestrating key events during neural development and neuritogenesis. Further exploration is warranted to elucidate the specific molecular mechanisms and downstream pathways through which CSPG5 contributes to these processes.

Species

Human

Source

HEK293

Tag

C-His

Accession

O95196-1 (V31-C423)

Gene ID
Molecular Construction
N-term
CSPG5 (V31-C423)
Accession # O95196-1
His
C-term
Synonyms
Chondroitin sulfate proteoglycan 5; Acidic leucine-rich EGF-like domain-containing brain protein; Neuroglycan C; CALEB; chondroitin sulfate proteoglycan 5 (neuroglycan C; MGC44034; Neuroglycan C; NGC; NGCAcidic leucine-rich EGF-like domain-containing brai
Molecular Weight

52-62 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

CSPG5 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CSPG5 Protein, Human (HEK293, His)
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HY-P77833
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