DCK/Deoxycytidine kinase Protein, Human (P. pastoris, His)

DCK/Deoxycytidine kinase Protein efficiently phosphorylates deoxyribonucleosides, including deoxycytidine, deoxyguanosine, and deoxyadenosine, showcasing broad substrate specificity without chirality selectivity. As an indispensable enzyme, DCK plays a crucial role in phosphorylating nucleoside analogs, vital in antiviral and chemotherapeutic treatments. Its catalytic ability contributes to therapeutic efficacy in nucleoside analog-based therapies, emphasizing its significance in cellular processes. DCK/Deoxycytidine kinase Protein, Human (P. pastoris, His) is the recombinant human-derived DCK/Deoxycytidine kinase protein, expressed by P. pastoris, with C-6*His labeled tag. The total length of DCK/Deoxycytidine kinase Protein, Human (P. pastoris, His) is 260 a.a., with molecular weight of 31.6 kDa.

DCK, known as deoxycytidine kinase, demonstrates its enzymatic prowess by effectively phosphorylating deoxyribonucleosides, including deoxycytidine, deoxyguanosine, and deoxyadenosine. With broad substrate specificity, this kinase does not exhibit selectivity based on the chirality of the substrate. Its significance extends to being an indispensable enzyme for the phosphorylation of various nucleoside analogs commonly utilized as antiviral and chemotherapeutic agents. The ability of DCK to catalyze the phosphorylation of nucleosides plays a crucial role in cellular processes and contributes to the therapeutic efficacy of nucleoside analog-based treatments.

Human

P. pastoris

C-6*His

P27707 (M1-L260)

1633  [NCBI]

MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL

31.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.