DOT1L Protein, Human

The DOT1L protein, a histone methyltransferase, methylates lysine-79 of histone H3. It shows high activity against nucleosomes but not free core histones. It is broadly expressed, particularly in tissues like the testis, bone marrow, and 22 other tissues. DOT1L Protein, Human is the recombinant human-derived DOT1L protein, expressed by E. coli , with tag free.

The DOT1L protein, a histone methyltransferase, is responsible for methylating lysine-79 of histone H3. While it does not exhibit significant activity against free core histones, it demonstrates substantial histone methyltransferase activity against nucleosomes. This protein is broadly expressed, with notable levels found in tissues such as the testis, bone marrow, and 22 other tissues.

Human

E. coli

Tag Free

Q8TEK3-1/NP_115871.1 (G2-K416)

84444  [NCBI]

Approximately 50 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.