2. Recombinant Proteins
  3. Receptor Proteins
  4. Cell Adhesion Molecules (CAMs)
  5. Cadherins
  6. DSC3/Desmocollin-3 Protein, Mouse (Cell-Free, His)

DSC3/Desmocollin-3 Protein, Mouse (Cell-Free, His)

Cat. No.: HY-P702265
Handling Instructions

DSC3 is a component of intercellular desmosome junctions and plays a key role in orchestrating complex interactions between plaque proteins and intermediate filaments, thereby promoting strong cell-to-cell adhesion. In addition to its adhesive function, DSC3 emerges as a potential contributor to epidermal cell localization, particularly in the context of cell stratification. DSC3/Desmocollin-3 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived DSC3/Desmocollin-3 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of DSC3/Desmocollin-3 Protein, Mouse (Cell-Free, His) is 761 a.a., with molecular weight of 86.3 kDa.

For research use only. We do not sell to patients.

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Description

DSC3 is a component of intercellular desmosome junctions and plays a key role in orchestrating complex interactions between plaque proteins and intermediate filaments, thereby promoting strong cell-to-cell adhesion. In addition to its adhesive function, DSC3 emerges as a potential contributor to epidermal cell localization, particularly in the context of cell stratification. DSC3/Desmocollin-3 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived DSC3/Desmocollin-3 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of DSC3/Desmocollin-3 Protein, Mouse (Cell-Free, His) is 761 a.a., with molecular weight of 86.3 kDa.
Background

Desmocollin-3 (DSC3) is a vital component of intercellular desmosome junctions, essential for mediating cell-cell adhesion. Operating within these junctions, DSC3 facilitates the interaction between plaque proteins and intermediate filaments, playing a crucial role in the structural integrity and stability of tissues. Notably, DSC3 may contribute to the positioning and stratification of epidermal cells by mediating differential adhesiveness between cells expressing different isoforms. This suggests its involvement in the regulation of cell arrangements within the epidermal layer. The multifaceted functions of DSC3 underscore its significance in cellular adhesion processes and tissue organization, emphasizing its role in maintaining the proper structure and function of various tissues. (
Species

Mouse
Source

E. coli Cell-free
Tag

N-10*His
Accession

P55850 (R136-R896)
Gene ID

13507
Molecular Construction
N-term
10*His
DSC2 (R136-R896)
Accession # P55850
C-term
Synonyms
Desmocollin-3
AA Sequence

RWAPIPCSMQENSLGPFPLFLQQVQSDAAQNYTVFYSISGRGADQEPLNWFFIERDTGNLYCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIKIEDENDNYPLFTEAIYAFEVPEGSRLGTVVGTVCATDKDEPDTMHTRLKYSILEQTPPSPGLFSVHPDTGVITTVSHYMDREVVDKYKLIMKVQDMNGQFFGLISTSTCIITVQDSNDNAPTFRQNTYETAVEENTYNVEILRIPVDDKDMINTANWKANFTILKGNENGWFKITTDPVTNEGVLCVVKPLDYEENRQVTLEIGVNNEAPFIKDVANRIPTMNRAMVTVHVKDQNEGPECKPPEQYVRIKENSAVGSKINGYKAYDPETKNSNGLRYKKLQDPKDWVSIEEVSGLLTISKTLDREIMAPRNDMYNITVMAIDQEGKSCTGTLAVNIEDVNDNAPEIIQDYIVICKPKMGYTDISAVDPDEPIHGPPFQFNLANTSPEVNRIWTLNQVNDTAARLSYQKTADVQIYNVPVTVKDRAGQSATKILRVNLCDCTHPSQCPLRSRSAGITLGKWAILAILLGIALLFSVLLTLVCGVVTARKGKHFPEDLAQQNLIISNTEAPGDDRVCSANGFTTHTANNSSQGFCGTMGSGMRNGGQETIEMMKGHQTLDSCRVAGHHHTLDSGRGGHMDTDNCRYTYSEWHSFTQPRLGEKLHVCNQNEDHIPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEEGLDFLNNLEPKFLTLAETCTKR

Molecular Weight

86.3 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

/
Documentation
Handling Instructions (2659 KB)

DSC3/Desmocollin-3 Protein, Mouse (Cell-Free, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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