DSG3 Protein, Human (His-SUMO)

DSG3 is a component of intercellular desmosome junctions and plays a key role in promoting intercellular adhesion by participating in important interactions with plaque proteins and intermediate filaments. Carefully orchestrated interactions between DSG3 and these structural elements are critical for maintaining the integrity and strength of cell-to-cell connections. DSG3 Protein, Human (His-SUMO) is the recombinant human-derived DSG3 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of DSG3 Protein, Human (His-SUMO) is 566 a.a., with molecular weight of ~79 kDa.

Desmoglein-3 (DSG3) is an integral component of intercellular desmosome junctions, playing a crucial role in mediating cell-cell adhesion. Functioning within these junctions, DSG3 is involved in the interaction between plaque proteins and intermediate filaments, contributing to the structural integrity and stability of tissues. Notably, DSG3 interacts with Plakophilin-2 (PKP2), emphasizing its role in coordinating the assembly and maintenance of desmosomal complexes. This interaction further highlights the intricate molecular network involved in cell-cell adhesion and reinforces the importance of DSG3 in ensuring the proper function and structural cohesion of tissues through its engagement in desmosomal signaling pathways. (

Human

E. coli

N-6*His;N-SUMO

P32926 (E50-R615)

1830  [NCBI]

EWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGR

Approximately 79 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.