ECSCR Protein, Mouse (HEK293, Fc)

ECSCR proteins are critical in angiogenesis, regulating endothelial chemotaxis, and tube formation. It regulates apoptosis by affecting the actin cytoskeleton and promoting proteasomal degradation of apoptosis inhibitors. ECSCR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived ECSCR protein, expressed by HEK293 , with C-hFc labeled tag.

The ECSCR protein plays a crucial role in regulating endothelial chemotaxis and tube formation, emphasizing its significance in angiogenesis (By similarity). Additionally, ECSCR contributes to apoptosis modulation by influencing the actin cytoskeleton and facilitating the proteasomal degradation of apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. These interactions underscore ECSCR's multifaceted involvement in cellular processes, influencing both angiogenesis and apoptosis. Furthermore, ECSCR interacts with FLNA, suggesting a potential link to the actin cytoskeleton dynamics, and with the 20S proteasome subunit PSMA7, indicating its participation in proteasomal degradation processes. These diverse molecular interactions highlight the central role of ECSCR in orchestrating complex cellular events that impact vascular development and cell survival mechanisms.

Mouse

HEK293

C-hFc

Q3TZW0-1 (Q19-T130)

68545  [NCBI]

48-68 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.