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  3. ECSCR Protein, Mouse (HEK293, Fc)

ECSCR Protein, Mouse (HEK293, Fc)

Cat. No.: HY-P77644
Handling Instructions

ECSCR proteins are critical in angiogenesis, regulating endothelial chemotaxis, and tube formation. It regulates apoptosis by affecting the actin cytoskeleton and promoting proteasomal degradation of apoptosis inhibitors. ECSCR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived ECSCR protein, expressed by HEK293 , with C-hFc labeled tag.

For research use only. We do not sell to patients.

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Description

ECSCR proteins are critical in angiogenesis, regulating endothelial chemotaxis, and tube formation. It regulates apoptosis by affecting the actin cytoskeleton and promoting proteasomal degradation of apoptosis inhibitors. ECSCR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived ECSCR protein, expressed by HEK293 , with C-hFc labeled tag.

Background

The ECSCR protein plays a crucial role in regulating endothelial chemotaxis and tube formation, emphasizing its significance in angiogenesis (By similarity). Additionally, ECSCR contributes to apoptosis modulation by influencing the actin cytoskeleton and facilitating the proteasomal degradation of apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. These interactions underscore ECSCR's multifaceted involvement in cellular processes, influencing both angiogenesis and apoptosis. Furthermore, ECSCR interacts with FLNA, suggesting a potential link to the actin cytoskeleton dynamics, and with the 20S proteasome subunit PSMA7, indicating its participation in proteasomal degradation processes. These diverse molecular interactions highlight the central role of ECSCR in orchestrating complex cellular events that impact vascular development and cell survival mechanisms.

Species

Mouse

Source

HEK293

Tag

C-hFc

Accession

Q3TZW0-1 (Q19-T130)

Gene ID
Molecular Construction
N-term
ECSCR (Q19-T130)
Accession # Q3TZW0-1
hFc
C-term
Synonyms
ARIA; ECSCR; ECSM2
Molecular Weight

48-68 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

ECSCR Protein, Mouse (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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ECSCR Protein, Mouse (HEK293, Fc)
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HY-P77644
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