2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. EGF Superfamily
  5. EGFL7/VE-Statin Protein, Mouse (sf9, His)

EGFL7/VE-Statin Protein, Mouse (sf9, His)

Cat. No.: HY-P75731
Handling Instructions

EGFL7/VE-Statin Protein regulates in vivo vascular tubulogenesis by inhibiting PDGF-BB-induced smooth muscle cell migration, promoting endothelial cell adhesion, and facilitating angiogenesis. It enhances endothelial cell motility through RGD-dependent interaction with ITGAV/ITGB3. EGFL7/VE-Statin Protein, Mouse (sf9, His) is the recombinant mouse-derived EGFL7/VE-Statin protein, expressed by Sf9 insect cells , with N-His labeled tag.

For research use only. We do not sell to patients.

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Description

EGFL7/VE-Statin Protein regulates in vivo vascular tubulogenesis by inhibiting PDGF-BB-induced smooth muscle cell migration, promoting endothelial cell adhesion, and facilitating angiogenesis. It enhances endothelial cell motility through RGD-dependent interaction with ITGAV/ITGB3. EGFL7/VE-Statin Protein, Mouse (sf9, His) is the recombinant mouse-derived EGFL7/VE-Statin protein, expressed by Sf9 insect cells , with N-His labeled tag.
Background

EGFL7/VE-Statin Protein plays a pivotal role in regulating vascular tubulogenesis in vivo. It exerts its effects by inhibiting platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration, promoting endothelial cell adhesion to the extracellular matrix, and facilitating angiogenesis. EGFL7/VE-Statin Protein interacts with ITGAV/ITGB3 in an RGD-dependent manner, thereby enhancing endothelial cell motility.
Species

Mouse
Source

Sf9 insect cells
Tag

N-His
Accession

Q9QXT5-1 (E22-L275)
Gene ID
Molecular Construction
N-term
His
EGFL7 (E22-L275)
Accession # Q9QXT5-1
C-term
Synonyms
Epidermal growth factor-like protein 7; NOTCH4-like protein; VE-statin; MEGF8
Molecular Weight

Approximately 34 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

EGFL7/VE-Statin Protein, Mouse (sf9, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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