1. Recombinant Proteins
  2. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  3. Ephrin/Eph Family Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. Eph Receptors
  5. EphB4
  6. EphB4 Protein, Mouse (HEK293, Fc)

EphB4 Protein, Mouse (HEK293, Fc)

Cat. No.: HY-P73004
Handling Instructions

Ephb4 Protein, a receptor tyrosine kinase, plays a critical role in angiogenesis and development. Dysregulation of Ephb4 Protein has been associated with disorders like cancer and cardiovascular diseases. Targeting Ephb4 Protein may provide potential therapeutic interventions in these conditions by modulating angiogenesis, inhibiting tumor growth, and managing cardiovascular complications. EphB4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphB4 protein, expressed by HEK293 , with C-hFc labeled tag.

For research use only. We do not sell to patients.

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Description

Ephb4 Protein, a receptor tyrosine kinase, plays a critical role in angiogenesis and development. Dysregulation of Ephb4 Protein has been associated with disorders like cancer and cardiovascular diseases. Targeting Ephb4 Protein may provide potential therapeutic interventions in these conditions by modulating angiogenesis, inhibiting tumor growth, and managing cardiovascular complications. EphB4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphB4 protein, expressed by HEK293 , with C-hFc labeled tag.

Background

Ephb4 Protein, a receptor tyrosine kinase, exhibits promiscuous binding to transmembrane ephrin-B ligands on neighboring cells, initiating contact-dependent bidirectional signaling. This leads to both forward signaling, downstream of the receptor, and reverse signaling, downstream of the ephrin ligand. Crucially, Ephb4 Protein, in conjunction with its cognate ligand EFNB2, regulates cell adhesion and migration, playing a pivotal role in heart morphogenesis, angiogenesis, blood vessel remodeling, and permeability. Notably, EPHB4-mediated forward signaling governs cellular repulsion and segregation from EFNB2-expressing cells.

Species

Mouse

Source

HEK293

Tag

C-hFc

Accession

P54761 (L16-A539)

Gene ID
Molecular Construction
N-term
EphB4 (L16-A539)
Accession # P54761-1
hFc
C-term
Synonyms
Ephrin type-B receptor 4; EPHB4; HTK; MYK1; TYRO11
AA Sequence

MELRALLCWASLATALEETLLNTKLETADLKWVTYPQAEGQWEELSGLDEEQHSVRTYEVCDMKRPGGQAHWLRTGWVPRRGAVHVYATIRFTMMECLSLPRASRSCKETFTVFYYESEADTATAHTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNIKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCSWLITNLTYFPETVPRELVVPVAGSCVANAVPTANPSPSLYCREDGQWAEQQVTGCSCAPGYEAAESNKVCRACGQGTFKPQIGDESCLPCPANSHSNNIGSPVCLCRIGYYRARSDPRSSPCTTPPSAPRSVVHHLNGSTLRLEWSAPLESGGREDLTYAVRCRECRPGGSCLPCGGDMTFDPGPRDLVEPWVAIRGLRPDVTYTFEVAALNGVSTLATGPPPFEPVNVTTDREVPPAVSDIRVTRSSPSSLILSWAIPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESESWREQLA

Molecular Weight

Approximately 110 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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EphB4 Protein, Mouse (HEK293, Fc)
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HY-P73004
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