EphB4 Protein, Mouse (HEK293, Fc)

Ephb4 Protein, a receptor tyrosine kinase, plays a critical role in angiogenesis and development. Dysregulation of Ephb4 Protein has been associated with disorders like cancer and cardiovascular diseases. Targeting Ephb4 Protein may provide potential therapeutic interventions in these conditions by modulating angiogenesis, inhibiting tumor growth, and managing cardiovascular complications. EphB4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EphB4 protein, expressed by HEK293 , with C-hFc labeled tag.

Ephb4 Protein, a receptor tyrosine kinase, exhibits promiscuous binding to transmembrane ephrin-B ligands on neighboring cells, initiating contact-dependent bidirectional signaling. This leads to both forward signaling, downstream of the receptor, and reverse signaling, downstream of the ephrin ligand. Crucially, Ephb4 Protein, in conjunction with its cognate ligand EFNB2, regulates cell adhesion and migration, playing a pivotal role in heart morphogenesis, angiogenesis, blood vessel remodeling, and permeability. Notably, EPHB4-mediated forward signaling governs cellular repulsion and segregation from EFNB2-expressing cells.

Immobilized Mouse Ephrin B2 His at 2 μg/ml (100 μl/well) can bind Mouse EphB4 hFc, the EC₅₀ of Mouse EphB4 hFc is 2.0-10.0 ng/mL.

Mouse

HEK293

C-hFc

P54761 (L16-A539)

13846  [NCBI]

MELRALLCWASLATALEETLLNTKLETADLKWVTYPQAEGQWEELSGLDEEQHSVRTYEVCDMKRPGGQAHWLRTGWVPRRGAVHVYATIRFTMMECLSLPRASRSCKETFTVFYYESEADTATAHTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNIKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCSWLITNLTYFPETVPRELVVPVAGSCVANAVPTANPSPSLYCREDGQWAEQQVTGCSCAPGYEAAESNKVCRACGQGTFKPQIGDESCLPCPANSHSNNIGSPVCLCRIGYYRARSDPRSSPCTTPPSAPRSVVHHLNGSTLRLEWSAPLESGGREDLTYAVRCRECRPGGSCLPCGGDMTFDPGPRDLVEPWVAIRGLRPDVTYTFEVAALNGVSTLATGPPPFEPVNVTTDREVPPAVSDIRVTRSSPSSLILSWAIPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESESWREQLA

Approximately 110 kDa

Greater than 95% as determined by reducing SDS-PAGE

Solution.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 7.5.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.