EphB6 Protein, Human (HEK293, His)

EphB6, a kinase-defective receptor, interacts with ephrin-B1 and ephrin-B2, regulating cell adhesion and migration. It inhibits JNK activation, reduces IL-2 secretion and CD25 expression in response to ephrin-B2. EphB6 interacts with CBL, EPHB1, and FYN, highlighting its multifaceted role in cellular signaling. EphB6 Protein, Human (HEK293, His) is the recombinant human-derived EphB6 protein, expressed by HEK293 , with C-His labeled tag.

EphB6, a kinase-defective receptor specializing in interactions with members of the ephrin-B family, serves as a binding partner for both ephrin-B1 and ephrin-B2. This receptor intricately regulates cell adhesion and migration, demonstrating a nuanced impact with both positive and negative effects upon stimulation by ephrin-B2. Particularly, EphB6 displays the ability to inhibit JNK activation and attenuate T-cell receptor-induced IL-2 secretion and CD25 expression when prompted by ephrin-B2. Noteworthy interactions include associations with CBL and EPHB1, as well as a ligand-independent interaction with FYN, unveiling the multifaceted nature of EphB6 in cellular signaling pathways.

Human

HEK293

C-His

O15197-1 (L32-S594)

2051  [NCBI]

60-70 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.