ERP27 Protein, Human (HEK293, His)

The ERP27 protein has a unique role in that it can specifically bind unfolded proteins and recruit the protein disulfide isomerase PDIA3 to the substrate through the hydrophobic pocket in its C-terminal domain. This interaction implies that ERP27 is involved in the unfolding stress response and resolves challenges in cellular proteostasis. ERP27 Protein, Human (HEK293, His) is the recombinant human-derived ERP27 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ERP27 Protein, Human (HEK293, His) is 248 a.a., with molecular weight of 32-38 kDa.

ERP27, a protein with a distinct role, exhibits specific binding to unfolded proteins and possesses the potential to recruit protein disulfide isomerase PDIA3 to unfolded substrates. This binding to protein substrates is facilitated through a hydrophobic pocket located in the C-terminal domain of ERP27. The protein's interaction with unfolded substrates suggests its potential involvement in the unfolded stress response, implying a role in cellular mechanisms addressing proteostasis challenges. Additionally, ERP27 engages in interactions with PDIA3, emphasizing its association with the intricate network of cellular proteins involved in protein folding and quality control. The specific molecular interactions and binding properties of ERP27 underscore its potential significance in cellular stress responses and protein homeostasis pathways.

Human

HEK293

C-6*His

Q96DN0 (E26-L273)

121506  [NCBI]

EVEKSSDGPGAAQEPTWLTDVPAAMEFIAATEVAVIGFFQDLEIPAVPILHSMVQKFPGVSFGISTDSEVLTHYNITGNTICLFRLVDNEQLNLEDEDIESIDATKLSRFIEINSLHMVTEYNPVTVIGLFNSVIQIHLLLIMNKASPEYEENMHRYQKAAKLFQGKILFILVDSGMKENGKVISFFKLKESQLPALAIYQTLDDEWDTLPTAEVSVEHVQNFCDGFLSGKLLKENRESEGKTPKVEL

32-38 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.