Erythropoietin Protein, Horse (His-SUMO)

Erythropoietin (EPO) is pivotal for erythrocyte regulation, maintaining the circulating erythrocyte mass. EPO binds to erythropoietin receptor (EPOR), inducing EPOR dimerization and activating JAK2. This initiates signaling pathways, including STAT1 and STAT3, crucial for governing erythropoiesis and ensuring overall red blood cell balance. Erythropoietin Protein, Horse (His-SUMO) is the recombinant Erythropoietin protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of Erythropoietin Protein, Horse (His-SUMO) is 166 a.a., with molecular weight of ~34.3 kDa.

Erythropoietin (EPO) is a vital hormone that regulates the proliferation and differentiation of erythrocytes, playing a crucial role in maintaining a physiological level of circulating erythrocyte mass. Through its binding to the erythropoietin receptor (EPOR), EPO induces EPOR dimerization and activates JAK2, initiating specific downstream signaling pathways. Notably, this cascade includes the activation of specific effectors such as STAT1 and STAT3, which collectively contribute to the intricate processes governing erythropoiesis and ensuring the overall balance of red blood cell levels.

Others

E. coli

N-6*His;N-SUMO

Q867B1 (A27-R192)

100033849  [NCBI]

APPRLICDSRVLERYILEAREAENVTMGCAEGCSFGENVTVPDTKVNFYSWKRMEVEQQAVEVWQGLALLSEAILQGQALLANSSQPSETLRLHVDKAVSSLRSLTSLLRALGAQKEAISPPDAASAAPLRTFAVDTLCKLFRIYSNFLRGKLKLYTGEACRRGDR

Approximately 34.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.