FAM172A Protein, Human (HEK293, His)

The FAM172A protein has multiple uses in the regulation of alternative splicing, interacting with AGO2 and CHD7 to coordinate RNA processing and chromatin modification. In addition to its role in splicing, FAM172A stabilizes protein-protein interactions at the chromatin-spliceosome interface, revealing multifaceted functions. FAM172A Protein, Human (HEK293, His) is the recombinant human-derived FAM172A protein, expressed by HEK293 , with C-6*His labeled tag.

FAM172A, a versatile protein, emerges as a crucial player in the intricate landscape of alternative splicing regulation. Its interaction with AGO2 and CHD7 suggests a pivotal role in orchestrating the dynamic interplay between RNA processing and chromatin modifications. Beyond its regulatory role in alternative splicing, FAM172A appears to contribute to the stabilization of protein-protein interactions at the chromatin-spliceosome interface, underscoring its multifaceted functions within cellular processes. Additionally, there are indications suggesting potential hydrolase activity, adding another layer to the diverse functions attributed to FAM172A. Within the cellular milieu, FAM172A forms a complex alongside AGO2 and CHD7, implying collaborative efforts in shaping the intricate landscape of RNA processing and chromatin dynamics.

Human

HEK293

C-6*His

Q8WUF8-1 (Q19-L416)

83989  [NCBI]

QIQQGGPDEKEKTTALKDLLSRIDLDELMKKDEPPLDFPDTLEGFEYAFNEKGQLRHIKTGEPFVFNYREDLHRWNQKRYEALGEIITKYVYELLEKDCNLKKVSIPVDATESEPKSFIFMSEDALTNPQKLMVLIHGSGVVRAGQWARRLIINEDLDSGTQIPFIKRAVAEGYGVIVLNPNENYIEVEKPKIHVQSSSDSSDEPAEKRERKDKVSKETKKRRDFYEKYRNPQREKEMMQLYIRENGSPEEHAIYVWDHFIAQAAAENVFFVAHSYGGLAFVELMIQREADVKNKVTAVALTDSVHNVWHQEAGKTIREWMRENCCNWVSSSEPLDTSVESMLPDCPRVSAGTDRHELTSWKSFPSIFKFFTEASEAKTSSLKPAVTRRSHRIKHEEL

40-60 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.