FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, HEK293, His)

The FCGRT protein transfers passive immunity by binding to monomeric IgG and facilitating its uptake from milk. It forms FcRn-IgG complexes that are transcytosed across the intestinal epithelium, releasing IgG into the bloodstream or tissue fluids. This receptor also recycles IgG, prolonging its half-life in circulation. Mechanistically, it binds to monomeric IgG in acidic endosomes, enabling recycling to the cell surface. The FCGRT-B2M heterodimer also regulates albumin homeostasis and consists of p51 and p14 subunits. FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing cynomolgus-derived FCGRT-B2M Heterodimer protein, expressed by HEK293, with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, HEK293, His), has molecular weight of ~31.9 & 11.6 KDa, respectively.

The FCGRT protein is a cell surface receptor that plays a critical role in transferring passive humoral immunity from the mother to the newborn. It accomplishes this by binding to the Fc region of monomeric immunoglobulin gamma and facilitating its selective uptake from milk. Within the intestinal epithelium, the FCGRT-B2M heterodimer binds to IgG at the apical surface, forming FcRn-IgG complexes that are transcytosed across the epithelium, releasing IgG into the bloodstream or tissue fluids. This receptor continues to contribute to effective humoral immunity throughout life by recycling IgG and prolonging its half-life in circulation. Mechanistically, the binding of monomeric IgG to FCGRT-B2M in acidic endosomes of endothelial and hematopoietic cells enables the recycling of IgG to the cell surface for release into the circulation. Additionally, the FCGRT-B2M heterodimer plays a role in regulating the homeostasis of albumin, the most abundant circulating protein, by interacting with it. The FCGRT-B2M complex consists of two subunits, p51 and p14 (equivalent to beta-2-microglobulin), forming an MHC class I-like heterodimer.

Cynomolgus

HEK293

C-His

Q8SPV9 (A24-S297)&Q8SPW0 (I21-M119)

102128913  [NCBI]&101867173  [NCBI]

Approximately 31.9&11.6 kDa.

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.