FGFR-4 Protein, Rhesus Macaque (HEK293, Fc)

The FGFR-4 protein is a cell surface receptor for tyrosine kinase and fibroblast growth factor. FGFR4, a receptor for FGF-1 and FGF-3 highly expressed in cancer cells, promotes tumor progression in colon cancer by activating Mek/Erk and MMP-7. FGFR-4 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived FGFR-4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FGFR-4 Protein, Rhesus Macaque (HEK293, Fc) is 369 a.a., with molecular weight of ~65.6 KDa.

FGFR-4 protein, as a cell surface receptor for tyrosine kinase and fibroblast growth factor, plays a key role in regulating multiple pathways, including cell proliferation, differentiation, migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. Structurally, the protein consists of an extracellular region with three immunoglobulin-like domains, a hydrophobic membrane span segment, and a cytoplasmic tyrosine kinase domain. Through the extracellular portion of its interaction with fibroblast growth factor, FGFR-4 initiates downstream signaling cascades that ultimately influence mitosis and differentiation. This gene showed widespread expression, with elevated levels observed in the lung (RPKM 16.7), kidney (RPKM 12.5), and 15 other tissues, underscoring its potential significance in different physiological Settings in different organs. FGFR4, a receptor for FGF-1 and FGF-3 highly expressed in cancer cells, promotes tumor progression in colon cancer by activating Mek/Erk and MMP-7^[1][2][3].

Rhesus Macaque

HEK293

C-mFc

XP_001087243 (M1-D369)

698494  [NCBI]

Approximately 65.6 kDa.

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.