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  6. FGFR-1 beta (IIIb) Protein, Human (HEK293, His)

FGFR-1 beta (IIIb) Protein, Human (HEK293, His)

Cat. No.: HY-P75766
Handling Instructions

FGFR-1 beta is a member of the FGFR family that interacts with fibroblast growth factors and regulates mitosis and differentiation. It specifically binds acidic and basic fibroblast growth factors and is involved in limb induction. FGFR-1 beta (IIIb) Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived FGFR-1 beta, expressed by HEK293 , with C-His labeled tag. FGFR-1 beta (IIIb) Protein, Human (HEK293, His), has molecular weight of 45-60 kDa.

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Description

FGFR-1 beta is a member of the FGFR family that interacts with fibroblast growth factors and regulates mitosis and differentiation. It specifically binds acidic and basic fibroblast growth factors and is involved in limb induction. FGFR-1 beta (IIIb) Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived FGFR-1 beta, expressed by HEK293 , with C-His labeled tag. FGFR-1 beta (IIIb) Protein, Human (HEK293, His), has molecular weight of 45-60 kDa.

Background

The FGFR-1 beta protein is a highly conserved member of the fibroblast growth factor receptor (FGFR) family, sharing a similar amino acid sequence with other members. FGFR family members exhibit different affinities for ligands and are distributed across various tissues. The full-length protein consists of an extracellular region with three immunoglobulin-like domains, a hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, initiating downstream signals that regulate mitogenesis and differentiation. FGFR-1 beta specifically binds to both acidic and basic fibroblast growth factors and plays a role in limb induction. Mutations in this gene have been associated with several syndromes and disorders, including Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Various alternatively spliced variants encoding different protein isoforms have been identified, although not all variants have been fully characterized. The FGFR-1 beta protein exhibits ubiquitous expression in multiple tissues, including the ovary, fat, and 25 other tissues.

Species

Human

Source

HEK293

Tag

C-His

Accession

NP_075594 (R22-K221&A270-E285)& AAB19502 (H1-P47)

Gene ID
Synonyms
Fibroblast growth factor receptor 1; FGFR-1; FGF R1b; FGFR1 beta
Molecular Weight

45-60 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

FGFR-1 beta (IIIb) Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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FGFR-1 beta (IIIb) Protein, Human (HEK293, His)
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HY-P75766
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