FGFRL1 Protein, Mouse (HEK293, His)

FGFRL1 protein significantly inhibits cell proliferation by interacting with FGF2 with low affinity, thereby regulating the proliferative signals associated with FGF2. This unique property positions FGFRL1 as a modulator of cellular growth, highlighting its intricate involvement in maintaining cellular homeostasis. FGFRL1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FGFRL1 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFRL1 Protein, Mouse (HEK293, His) is 354 a.a., with molecular weight of ~55-68 KDa.

FGFRL1, a pivotal player in cellular dynamics, exerts a noteworthy negative impact on cell proliferation. Its interaction with FGF2 is characterized by a low affinity, emphasizing its regulatory role in mitigating the proliferative signals associated with FGF2. This distinctive property positions FGFRL1 as a modulator of cellular growth processes, shedding light on its intricate involvement in cellular homeostasis.

Immobilized human bFGF at 5 μg/mL (100 μL/well) can bind mouse FGFR5. The ED₅₀ for this effect is 0.9066 μg/mL.

Mouse

HEK293

C-His

Q91V87 (A21-P374)

116701  [NCBI]

ARGPPRMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKEVEAEDAGVYVCKATNGFGSLSVNYTLIIMDDISPGKESPGPGGSSGGQEDPASQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDIMWMKDDQTLTHLEASEHRKKKWTLSLKNLKPEDSGKYTCRVSNKAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGSEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLISRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPMASSSSSTSLPWP

Approximately 55-68 kDa.

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.