Ficolin-1 Protein, Rhesus Macaque (HEK293, Fc)

Ficolin-1 functions locally after inflammatory lesions in monocyte, macrophage, and granulocyte secretion, and is also present in serum, suggesting that it may play a role in systemic immunity. Ficolins recognize and bind to pathogens, leading to neutralization and conditioning, which subsequently activates the complement lectin pathway. Ficolin-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived Ficolin-1 protein, expressed by HEK293 , with C-hFc labeled tag.

Lectins are classified as C-type lectins. C-type lectins are carbohydrate-binding proteins that require calcium to bind. Ficolins recognize and bind to pathogens, leading to neutralization and conditioning, which subsequently activates the complement lectin pathway. Ficolin-1 functions locally after inflammatory lesions in monocyte, macrophage, and granulocyte secretion, and is also present in serum, suggesting that it may play a role in systemic immunity. Ficolin-1 is assembled on the cell surface via its fibrin-as-is domain and accepts sialic acid as a ligand^[1][2].

Rhesus Macaque

HEK293

C-hFc

XP_001098002.1 (A30-A326)

712405  [NCBI]

Approximately 59.1 kDa.

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.