1. Recombinant Proteins
  2. CAR-T Related Proteins Receptor Proteins Fluorescent-labeled Recombinant Proteins
  3. Folate Receptor alpha (FR-alpha)
  4. FITC-Labeled FOLR1 Protein, Human (HEK293, His)

FITC-Labeled FOLR1 Protein, Human (HEK293, His)

Cat. No.: HY-P701278
Handling Instructions

The FOLR1 protein is an important mediator of folate uptake, binding to folate and promoting the delivery of 5-methyltetrahydrofolate into cells. Studies show high affinity at neutral pH. FITC-Labeled FOLR1 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled FOLR1 protein, expressed by HEK293 , with His labeled tag. The total length of FITC-Labeled FOLR1 Protein, Human (HEK293, His) is 209 a.a., with molecular weight of 35-43 kDa.

For research use only. We do not sell to patients.

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Description

The FOLR1 protein is an important mediator of folate uptake, binding to folate and promoting the delivery of 5-methyltetrahydrofolate into cells. Studies show high affinity at neutral pH. FITC-Labeled FOLR1 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled FOLR1 protein, expressed by HEK293 , with His labeled tag. The total length of FITC-Labeled FOLR1 Protein, Human (HEK293, His) is 209 a.a., with molecular weight of 35-43 kDa.

Background

The FOLR1 protein functions as a key mediator in folate uptake, binding to folate and reduced folic acid derivatives to facilitate the delivery of 5-methyltetrahydrofolate and folate analogs into the cell interior. This process is characterized by a high affinity for folate and folic acid analogs at neutral pH, as evidenced by various studies. Notably, exposure to a slightly acidic pH following receptor endocytosis induces a conformational change that significantly reduces its affinity for folates, facilitating their release. Beyond its role in folate transport, FOLR1 is essential for normal embryonic development and proper cell proliferation, underlining its significance in fundamental cellular processes.

Species

Human

Source

HEK293

Tag

His

Accession

P15328 (R25-M233)

Gene ID

2348

Synonyms
FOLR-1; FBP; FOLR; FRα
Molecular Weight

35-43 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

FITC-Labeled FOLR1 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
FITC-Labeled FOLR1 Protein, Human (HEK293, His)
Cat. No.:
HY-P701278
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